Graphene-encapsulated magnetic nanoparticles for safe and steady delivery of ferulic acid in diabetic mice

Iron nanoparticles encapsulated within graphene shells ([email protected]) were examined for cellular internalization, subcellular behavior, biocompatibility, and influence on cell viability proliferation. Studies human lung (adenocarcinoma alveolar basal epithelial) skin (epidermoid carcinoma) cells indicate [email protected] is less toxic more biocompatible than the magnetite coated by an amorphous carbon (Fe3O4@C). Fe3O4@C exhibited signs of degradation when exposed to murine macrophages (mouse monocyte-macrophages J774). Unlike Fe3O4@C, has a high drug loading capacity (0.18 g/g) ferulic acid, active pharmaceutical ingredient found in traditional Chinese herb Angelica sinensis releases at constant dosing rate 8.75 mg/g/day over 30 days. Ferulic acid released injected subcutaneously diabetic BALB/c mice effective lowering blood glucose level.